Topic
Humanin
Everything we've written on Humanin — 6 articles covering the mechanism, the evidence, comparisons, and practical considerations.
6 articles
Mitochondrial healthWhat people are reporting about HumaninThis article summarizes experiences reported in public online communities including Reddit, longevity forums, and discussion boards. We are not advocating human use of any compound discussed here. Many of the peptides discussed are not FDA-approved for the uses described, and some are explicitly not approved for human or veterinary use. What follows is a synthesis of what people have reported, presented to give readers context on the public conversation — not as guidance, not as evidence of safety or efficacy, and not as a recommendation. Decisions about any compound should be made with a qualified prescribing provider after a full medical evaluation.8 min readMitochondrial healthHumanin — the mitochondrial peptide that protects neuronsIn 2001, in a laboratory in Tokyo, a researcher named Yuichi Hashimoto was trying to understand why some neurons survive exposure to amyloid-beta and some don't. Alzheimer's disease research at that point was already deeply invested in the amyloid hypothesis — the idea that the accumulation of amyloid-beta peptide fragments is the initiating event in the disease — but the mechanism of neuronal death was still being worked out. Hashimoto's group was screening a library of expressed sequences from the brain tissue of Alzheimer's patients, looking for something that could explain or counteract the toxicity. What they found was not what they were looking for.8 min readCognitive supportHumanin in Alzheimer's and neurodegenerative researchYou forget a name at a party and you're not sure whether it's nothing or the beginning of something. The forgetting itself isn't new — names have always been slippery — but the anxiety about the forgetting is new, and there's a quality to it that's different from forgetting where you put your keys. Keys have a logic to where they could be. A name you knew ten minutes ago has no logic to offer you. You stand there and there's just a gap, and the gap has a weight to it.8 min readMitochondrial healthNAD+ vs MOTS-c vs SS-31 vs Humanin — the mitochondrial peptide stack, decodedYou got your labs back and your biological age came out higher than your chronological age. Or the fatigue is real — not the kind that coffee fixes, not the kind that a good night's sleep fully resolves — a deeper, structural tiredness that has started to feel like a baseline rather than a symptom. Or you've been researching longevity seriously and you've arrived at the mitochondria, because the research keeps pointing there: cellular energy, oxidative stress, the gradual degradation of the organelles that power everything else. You've encountered four names being discussed — NAD+, MOTS-c, SS-31, Humanin — and you want to understand what each actually does, why they're being discussed together, and whether the combination logic holds up.7 min readOrigins and discoveryMOTS-c — the peptide your mitochondria write themselvesIn 2015, a research team at the University of Southern California published a paper in Cell Metabolism that quietly changed the way biologists had to think about the mitochondrion. The paper was not loudly announced outside specialist circles. It didn't generate the cultural noise that cancer immunotherapy or CRISPR news generated that same year. But what Pinchas Cohen, Changhan Lee, and their colleagues described was a genuine reclassification — a finding that required updating a story about cellular biology that had been told, largely without revision, since the 1960s.8 min readImmune modulationPeptides for hearing and tinnitus — what research has exploredYou're in your early fifties and you start noticing it in restaurants. The person across from you is speaking at a normal volume, the room is not especially loud, and you are leaning forward without quite meaning to. The words arrive but some of the consonants are missing — the sibilants, the soft endings of words. You fill in the gaps from context and it works most of the time, which is why you don't mention it, which is why it continues without a name for another year or two. Then there's the other thing: a tone in one ear, or both, that no one else can hear. High-frequency, continuous, most noticeable when the room goes quiet. At three in the morning it is very noticeable.9 min read