Concern
3 plain-language articles on energy & mitochondria — the physiology, the compounds researched for it, and what the evidence actually shows.
3 articles
Mitochondrial fatigue: the energy problem doctors miss
You sleep eight hours and wake up flat. Coffee gets you to noon, then you crash. Workouts that used to feel good now feel like work for three days afterward. Labs come back normal — thyroid in range, ferritin fine, B12 fine, CBC unremarkable — and the verdict is some version of "everything looks good, try to manage your stress." If you've been told you're always tired for no reason, the reason is usually real. It just isn't on the standard panel.
NAD+ and cellular aging in plain English
If you've spent any time inside the longevity conversation, you've heard the term. NAD+ is on every supplement shelf, in every podcast, on the cover of every popular-science book about aging. What it isn't, in most of those places, is explained — what it actually does inside a cell, why levels drop with age, and why that drop matters for how you feel and how you age. Here's the plain-English version.
NAD+ and CD38 — why supplementing alone might not be enough
You start taking NMN. Your NAD+ levels come up, at least on a blood test. Three months later, maybe six, the effect seems to blunt. You're still taking it, the dose hasn't changed, but something about the initial lift has flattened. Maybe you increase the dose. Maybe it helps. Maybe it doesn't. You've entered a conversation that the supplement marketing doesn't prepare you for: that raising NAD+ levels is not just a question of what you put in, but of what's consuming it on the other end — and that consumption is running faster as you age.