ENDO-205

ENDO-205 — the first peptide designed to remove endometriosis lesions, not just quiet them

For decades the menu for endometriosis has had two items on it, and both leave the disease itself largely in place. A surgeon can excise the visible implants, and a clinician can lower estrogen — with a pill, a progestin, a GnRH analogue, or a levonorgestrel IUD — to quiet the bleeding and the pain. Neither switches off the biology that regrows the lesions, which is why recurrence is common and why so many women cycle through repeat surgeries and a rotating cast of hormonal regimens that manage symptoms without resolving the thing producing them. The lesion is treated as tissue to cut out or as estrogen to suppress. It is rarely treated as a target in its own right.